25C-NBOMe (NBOMe-2C-C, 2C-C-NBOMe, Cimbi-82) is a psychedelic drug and derivative of the psychedelic phenethylamine 2C-C. 25C-NBOMe appeared on online vendor sites in 2010 but was not reported in the literature until 2011. It acts as a potent agonist for the 5HT2A receptor, and has been studied in its 11C radiolabelled form as a potential ligand for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography (PET).
25C-NBOMe is derived from the psychedelic phenethylamine 2C-C by substitution on the amine with a 2-methoxybenzyl group. 25C-NBOMe is a clumpy white powder with a notably bitter and metallic taste. 25C-NBOMe has been found on blotter mimics sold as LSD.
Blotter paper containing 25C-NBOMe
Anecdotal reports from human users suggest 25C-NBOMe to be an active hallucinogen at a dose of as little as 200-500 µg insufflated and 300-600 µg buccaly (with threshold doses even lower), making it only half to a third the potency of LSD. NBOMe-substituted compounds have a diminished absorption rate passing through mucus membranes, but generally remain inactive when taken orally. Buccal, sublingual or insufflated routes of administration are all viable options. Absorption rate buccally and sublingually can be increased when complexed with HPBCD complexing sugar, however the most efficient is nasal administration, which shortens the duration while increasing intensity, but has been attributed to several overdoses due to improper dosing.
(Includes negative side effects arising from overdose; likelihood of negative side effects increases with dose)
Toxicity and harm potential
25C-NBOMe overdoses have been linked to multi-organ failure.
Drug prohibition laws
As of October 31, 2016; 25C-NBOMe is a controlled substance (Schedule III) in Canada. http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php
The NBOMe series of psychoactives became controlled in Israel in May, 2013.
25C-NBOMe was sold as a designer drug in New Zealand in early 2012, but was withdrawn from sale after a statement by Associate Health Minister Peter Dunne that 25C-NBOMe would be considered to be substantially similar in chemical structure to the illegal hallucinogen DOB, and was therefore a Class C controlled drug analogue.
Russia became the first country to regulate the NBOME class. The entire NBOMe series of psychoactives became controlled in the Russian Federation starting October, 2011.
Sveriges riksdag added 25C-NBOMe to schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of Aug 1, 2013, published by Medical Products Agency in their regulation LVFS 2013:15 listed as 25C-NBOMe 2-(4-kloro-2,5-dimetoxifenyl)-N-(2-metoxibensyl)etanamin.
This substance is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.
Several NBOMe series compounds will be temporarily scheduled in the United States for 2 years. The temporary scheduling applies to 25C-NBOMe, 25B-NBOMe, and 25I-NBOMe. In November 2015, the temporary scheduling was extended for another year.
As of October 2015 25C-NBOMe is a controlled substance in China.
25C-NBOMe is banned in the Czech Republic.
Analogues and derivatives
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- ^ Hansen, M.; Phonekeo, K.; Paine, J. S.; Leth-Petersen, S.; Begtrup, M.; Bräuner-Osborne, H.; Kristensen, J. L. (2014). "Synthesis and Structure-Activity Relationships of N-Benzyl Phenethylamines as 5-HT2A/2C Agonists". ACS Chemical Neuroscience. 5 (3): 243-9. doi:10.1021/cn400216u. PMC 3963123 . PMID 24397362.
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- ^ Zuba, D.; Seku?a, K.; Buczek, A. (2013). "25C-NBOMe - New potent hallucinogenic substance identified on the drug market". Forensic Science International. 227 (1-3): 7-14. doi:10.1016/j.forsciint.2012.08.027. PMID 22989597.
- ^ 2C-C-NBOMe Dose - erowid
- ^ a b S. Grautoff; J. Kähler (May 2014). "Lebensgefährliche Intoxikation mit der neuen psychoaktiven Substanz 25C-NBOMe". Medizinische Klinik - Intensivmedizin und Notfallmedizin (in German). 109 (4): 271-275. doi:10.1007/s00063-014-0360-5. PMID 24770890.
- ^ Tarpgaard M, Mærkedahl R, Lauridsen KB (August 2015). "Fatalt forløb efter intoksikation med det nye designerdrug 25C-NBOMe". Ugeskrift for Laeger (in Danish). 177 (35). PMID 26324189.
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