Lapides began her career as a visual and performance artist in New York. She continues to exhibit in group shows.
By 1990 Lapides and her partner and husband Greg Miller had moved to Los Angeles. In 1993 they created Un-Cabaret, a live show that became an important venue for the Los Angeles "alternative comedy" movement. Notable shows that emerged from the Un-Cabaret included Julia Sweeney's God Said, 'Ha! and Laura Kightlinger's book Quick Shots of False Hope. Spin-off productions from the Un-Cabaret have included Say the Word, a story-telling show; The Other Network, a show featuring unaired pilots, and the Un-Cab Lab, a student workshop.
Lapides's first book Did I Wake You?--Haikus for Modern Living was published in 2007.
Lapides has created several one-person shows and performance pieces, including a satirical 1992 campaign to be elected First Lady, a 2007 show based on her book of haiku, and a recent production entitled 100% Happy 88% of the Time.
Lapides appeared in the famous "Sex and the City" TV series as a performance artist who doesn't speak or eat in the "One" episode (2003).