Eupatorium perfoliatum or (common) boneset is a common North American perennial plant in the aster family. It is native to the Eastern United States and Canada, widespread from Nova Scotia to Florida, west as far as Texas, Nebraska, the Dakotas, and Manitoba. It is also called "agueweed", "feverwort" or "sweating-plant". It was introduced to American colonists by Indians who used the plant for breaking fevers by means of heavy sweating. It is nearly always found in low, wet areas and is often found near Phalaris arundinacea (reed canary grass).
Eupatorium perfoliatum grows up to 100 cm (39 inches) tall, with leaves that clasp the stems. The plant produces dense clusters of tiny white flower heads held above the foliage.
Eupatorium perfoliatum was used in the traditional medicine of Native Americans and extracts are now used in herbal medicine for fever and colds. The effects of Eupatorium perfoliatum have not been confirmed by clinical study. However, animal studies and in vitro experiments with plant extracts indicate possible anti-inflammatory effects and activity against Plasmodium falciparum, the parasite that causes malaria.
The leaves growing together around the stem lead to a past superstition that wrapping the leaves in bandages around splints would help broken bones set. Boneset also had other medical uses, and was a very common remedy in the United States in the 19th century.
Eupatorium perfoliatum is a specific butterfly food and habitat plant. It provides nectar for butterflies in the adult life cycle stage, particularly the White M hairstreak and the Bronze Copper butterfly.