|NeuroLex ID||Glossopharyngeal nerve fiber bundle|
|Anatomical terms of neuroanatomy|
The glossopharyngeal nerve, known as the ninth cranial nerve (CN IX), is a mixed nerve that carries afferent sensory and efferent motor information. It exits the brainstem out from the sides of the upper medulla, just rostral (closer to the nose) to the vagus nerve. The motor division of the glossopharyngeal nerve is derived from the basal plate of the embryonic medulla oblongata, while the sensory division originates from the cranial neural crest.
From the anterior portion of the medulla oblongata, the glossopharyngeal nerve passes laterally across or below the flocculus, and leaves the skull through the central part of the jugular foramen. From the superior and inferior ganglia in jugular foramen, it has its own sheath of dura mater. The inferior ganglion on the inferior surface of petrous part of temporal is related with a triangular depression into which the aqueduct of cochlea opens. On the inferior side, the glossopharyngeal nerve is lateral and anterior to the vagus nerve and accessory nerve.
In its passage through the foramen (with X and XI), the glossopharyngeal nerve passes between the internal jugular vein and internal carotid artery. It descends in front of the latter vessel and beneath the styloid process and the muscles connected with it, to the lower border of the stylopharyngeus. It then curves forward, forming an arch on the side of the neck and lying upon the stylopharyngeus and middle pharyngeal constrictor muscle. From there, it passes under cover of the hyoglossus muscle and is finally distributed to the palatine tonsil, the mucous membrane of the fauces and base of the tongue, and the serous glands of the mouth.
Note: The glossopharyngeal nerve contributes in the formation of the pharyngeal plexus along with the vagus nerve.
The glossopharyngeal nerve has five distinct general functions:
The glossopharyngeal nerve as noted above is a mixed nerve consisting of both sensory and motor nerve fibers. The sensory fibers' origin include the pharynx, middle ear, posterior one-third of the tongue (including taste buds); and the carotid body and sinus. These fibers terminate at the medulla oblongata. The motor fibers' origin is the medulla oblongata, and they terminate at the parotid salivary gland, the glands of the posterior tongue, and the stylopharyngeus muscle (which dilates the pharynx during swallowing).
The branchial motor component of CN IX provides voluntary control of the stylopharyngeus muscle, which elevates the pharynx during swallowing and speech.
Origin and central course
The branchial motor component originates from the nucleus ambiguus in the reticular formation of the medulla Rostral medulla. Fibers leaving the nucleus ambiguus travel anteriorly and laterally to exit the medulla, along with the other components of CN IX, between the olive and the inferior cerebellar peduncle.
Upon emerging from the lateral aspect of the medulla the branchial motor component joins the other components of CN IX to exit the skull via the jugular foramen. The glossopharyngeal fibers travel just anterior to the cranial nerves X and XI, which also exit the skull via the jugular foramen.
Extra-cranial course and final innervation
Voluntary control of the stylopharyngeus muscle
Signals for the voluntary movement of stylopharyngeus muscle originate in the pre-motor and motor cortex (in association with other cortical areas) and pass via the corticobulbar tract in the genu of the internal capsule to synapse bilaterally on the ambiguus nuclei in the medulla.
Parasympathetic component of the glossopharyngeal nerve that innervates the ipsilateral parotid gland.
Origin and central course
The preganglionic nerve fibers originate in the inferior salivatory nucleus of the rostral medulla and travel anteriorly and laterally to exit the brainstem between the medullary olive and the inferior cerebellar peduncle with the other components of CN IX. Note: These neurons do not form a distinct nucleus visible on cross-section of the brainstem. The position indicated on the diagram is representative of the location of the cell bodies of these fibers.
Upon emerging from the lateral aspect of the medulla, the visceral motor fibers join the other components of CN IX to enter the jugular foramen. Within the jugular foramen, there are two glossopharyngeal ganglia that contain nerve cell bodies that mediate general, visceral, and special sensation. The visceral motor fibers pass through both ganglia without synapsing and exit the inferior ganglion with CN IX general sensory fibers as the tympanic nerve. Before exiting the jugular foramen, the tympanic nerve enters the petrous portion of the temporal bone and ascends via the inferior tympanic canaliculus to the tympanic cavity. Within the tympanic cavity the tympanic nerve forms a plexus on the surface of the promontory of the middle ear to provide general sensation. The visceral motor fibers pass through this plexus and merge to become the lesser petrosal nerve. The lesser petrosal nerve re-enters and travels through the temporal bone to emerge in the middle cranial fossa just lateral to the greater petrosal nerve. It then proceeds anteriorly to exit the skull via the foramen ovale along with the mandibular nerve component of CN V (V3).
Extra-cranial course and final innervations
Upon exiting the skull, the lesser petrosal nerve synapses in the otic ganglion, which is suspended from the mandibular nerve immediately below the foramen ovale. Postganglionic fibers from the otic ganglion travel with the auriculotemporal branch of CN V3 to enter the substance of the parotid gland.
Fibers from the hypothalamus and olfactory system project via the dorsal longitudinal fasciculus to influence the output of the inferior salivatory nucleus. Examples include: 1) dry mouth in response to fear (mediated by the hypothalamus); 2) salivation in response to smelling food (mediated by the olfactory system)
This component of CN IX innervates the baroreceptors of the carotid sinus and chemoreceptors of the carotid body.
This component of CN IX carries general sensory information (pain, temperature, and touch) from the skin of the external ear, internal surface of the tympanic membrane, the walls of the upper pharynx, and the posterior one-third of the tongue.
Clinical correlation. The general sensory fibers of CN IX mediate the afferent limb of the pharyngeal reflex in which touching the back of the pharynx stimulates the patient to gag (i.e., the gag reflex). The efferent signal to the musculature of the pharynx is carried by the branchial motor fibers of the vagus nerve.
The special sensory component of CN IX provides taste sensation from the posterior one-third of the tongue.
The glossopharyngeal nerve is mostly sensory. The glossopharyngeal nerve also aids in tasting, swallowing and salivary secretions. Its superior and inferior (petrous) ganglia contain the cell bodies of pain fibers. It also projects into many different structures in the brainstem:
There are a number of functions of the glossopharyngeal nerve:
Damage to the glossopharyngeal nerve can result in loss of taste sensation to the posterior one third of the tongue, and impaired swallowing.
The clinical tests used to determine if the glossopharyngeal nerve has been damaged include testing the gag reflex of the mouth, asking the patient to swallow or cough, and evaluating for speech impediments. The clinician may also test the posterior one-third of the tongue with bitter and sour substances to evaluate for impairment of taste.
The integrity of the glossopharyngeal nerve may be evaluated by testing the patient's general sensation and that of taste on the posterior third of the tongue. The gag reflex can also be used to evaluate the glossphyaryngeal nerve, but also tests the vagus nerve, as only the afferent fibres involved in the reflex are carried by the glossopharyngeal nerve.
Saladin, Anatomy and Physiology: The Unity of Form and Function, 6th edition