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JWH-359 structure.png
Chemical and physical data
Molar mass356.540 g/mol
3D model (JSmol)

JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective CB2 receptor agonist, with a Ki of 13.0 nM and selectivity of around 220 times for CB2 over CB1 receptors. It is related to other dibenzopyran CB2 agonists such as JWH-133 and L-759,656 but with a chiral side chain which has made it useful for mapping the shape of the CB2 binding site.[1][2] It was discovered by, and named after, John W. Huffman.


  1. ^ Huffman, J.; Bushell, S.; Joshi, S.; Wiley, J.; Martin, B. (2006). "Enantioselective synthesis of 1-methoxy- and 1-deoxy-2'-methyl-delta8-tetrahydrocannabinols: new selective ligands for the CB2 receptor". Bioorganic & Medicinal Chemistry. 14 (1): 247-262. doi:10.1016/j.bmc.2005.08.013. PMID 16165365.
  2. ^ "Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor". Curr Top Med Chem. 8 (3): 187-204. 2008. doi:10.2174/156802608783498014. PMID 18289088.

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