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Legal status
Legal status
CAS Number
Chemical and physical data
Formula C24H22ClNO
Molar mass 375.890 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3nM and 2.8nM at CB2.[2] It was identified by the EMCDDA as an ingredient in three separate "herbal incense" products purchased from online shops between February to June 2009.[3] It was discovered by, and named after, Dr. John W. Huffman.[4]

See also


  1. ^ [1]
  2. ^ Huffman JW (2009) Cannabimimetic indoles, pyrroles, and indenes: structure-activity relationships and receptor interactions. Cited in: The cannabinoid receptors, Reggio PH (Ed), Humana Press. ISBN 978-1-58829-712-9 doi:10.1007/978-1-59745-503-9
  3. ^ Understanding the 'Spice' phenomenon. EMCDDA, Lisbon, November 2009
  4. ^ John W. Huffman, et al. STRUCTURE-ACTIVITY RELATIONSHIPS AT THE CB1 AND CB2 RECEPTORS FOR 1-ALKYL-3-(1-NAPHTHOYL-4 AND 8-HALOGEN SUBSTITUTED) INDOLES (2009) 19th Annual Symposium on the Cannabinoids, Burlington, Vermont, International Cannabinoid Research Society, Page 2.

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