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Botanists recognize this area as a dispersal route of plant species.
The distribution of Y-chromosome and mtDNA haplogroups suggests that during the Paleolithic and Mesolithic periods, the Levantine corridor was more important for bi-directional human migrations between Africa and Eurasia than was the Horn of Africa.
The first sedentary villages were established around fresh water springs and lakes in the Levantine corridor by the Natufian culture. The term is used frequently by archaeologists as an area that includes Cyprus, where important developments occurred during the Neolithic revolution.