Born on 17 March 1878, 26 rue d'Édimbourg, in the 8th arrondissement of Paris, where the Monets had moved from Argenteuil, Michel Monet was the younger of Claude and Camille Monet's two sons. His mother's already failing health worsened after his birth and she died on 5 September 1879, probably of uterine cancer. Michel's elder brother, Jean, was born in 1867.
Since 1877, year of Ernest Hoschedé's bankruptcy, Alice Hoschedé and her six children had been living with the Monets. The two families moved from Paris to Vétheuil in August 1878 and after Camille's death in 1879, Monet, Alice and the eight children continued living together. In 1881, they moved to Poissy and in April 1883 to Giverny. Alice managed the household and supervised the education of the Monet and Hoschedé children.
When Claude Monet died in 1926, as his sole heir, Michel inherited the entire estate. Michel never spent time in Giverny and Blanche Hoschedé Monet, his stepsister and sister-in-law, became the caretaker of the house and garden until her death in 1947. Louis Lebret, who had been Monet's head gardener, stayed on to help Blanche. After her death the garden was neglected.
Michel Monet, a car enthusiast, died in a car crash in nearby Vernon on 3 February 1966, a few weeks before his 88th birthday. He had bequeathed the estate to the Académie des beaux-arts. From 1977 onwards, Gérald Van der Kemp, then curator at the Château de Versailles, played a key role in the restoration of Claude Monet's house and gardens, which had been left in a desolate state. In a bid to raise funds, he and his wife Florence appealed to American donors through the "Versailles Foundation-Giverny Inc."
In 1966, Michel Monet had left to the Musée Marmottan Monet his own collection of his father's work, thus creating the world's largest collection of Monet paintings.
Michel Monet is buried in Claude Monet's vault in the Giverny cemetery, which adjoins the village Sainte Radegonde church. In Claude Monet's vault are buried Claude, his second wife Alice, his son Jean, Alice's first husband Ernest Hoschedé, Michel's wife Gabrielle, and Claude's daughter-in-law Blanche.