Psi-DOM
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Psi-DOM
Psi-DOM
2,6-dimethoxy-4-methylamphetamine.svg
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
ChEMBL
Chemical and physical data
Formula C12H19NO2
Molar mass 209.29 g/mol
3D model (JSmol)
Melting point 203 °C (397 °F)
 ?N?Y (what is this?)  (verify)

?-DOM, or 2,6-dimethoxy-4-methylamphetamine, is a hallucinogenic, psychedelic drug and a structural isomer of the better-known hallucinogen DOM. ?-DOM was first reported by Alexander Shulgin in his book PiHKAL (Phenethylamines i Have Known And Loved).

?-DOM has similar effects to DOM, but is only around 1/3 - 1/2 the potency, with an active dose reported to be between 15-25 milligrams. The effects of ?-DOM last for around 6-8 hours.

The activity of ?-DOM (and ?-2C-T-4) demonstrates that the two methoxy groups on the psychedelic phenethylamines are not strictly limited to the 2,5 positions on the phenyl ring. Indeed, any of the 2Cx or DOx series of drugs could alternatively be made as the 2,6 isomer and would still be expected to show similar activity, although slightly less potent. In theory this would vastly expand the range of different hallucinogens that could be derived from this family of drugs. The 2,6 isomer of another similar drug 2C-D-FLY (see 2C-B-FLY) has also been made by David E. Nichols and found to be active,[1] this might by extension be referred to as ?-2C-D-FLY.

?-2C-D-FLY

References

  1. ^ Chambers JJ, Kurrasch-Orbaugh DM, Nichols DE. Translocation of the 5-Alkoxy Substituent of 2,5-Dialkoxyarylalkylamines to the 6-Position: Effects on 5-HT2A/2C Receptor Affinity. Bioorganic & Medicinal Chemistry Letters (2002); (12):1997-1999

External links


  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.

Psi-DOM
 



 

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