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science.tv was founded by Matt Thurling, a digital media pioneer and film-maker based in Bristol, England. Research and development work began in 2005  and the site was launched in December 2007. Thurling writes the science.tv blog, where he sets out the vision for the site and invites feedback and suggestions for improvements.
The .tv ("dot-tv") extension is a Top-level domain name, originally associated with the Polynesian island nation of Tuvalu. The entire domain was purchased from the islands' residents in 2000  and the suffix is now increasingly being used for sites featuring, or relating to, video content.
The focus of science.tv is user-generated content, and much of the content on the site is actually embedded from other video sites, including YouTube. The intended audience is broad, ranging from school students to academics and professional programme-makers. Users are able to navigate for content via site-wide search, tags and by preset categories, which include: physics, chemistry and biology.