The sleep cycle is an oscillation between the slow-wave and REM (paradoxical) phases of sleep, sometimes called the ultradian sleep cycle, sleep-dream cycle, or REM-NREM cycle, to distinguish it from the circadian alternation between sleep and wakefulness. In humans this cycle takes 1-2 hours.
Electroencephalography readily shows the timing of sleep cycles by virtue of the marked distinction in brainwaves manifested during REM and non-REM sleep. Delta wave activity, correlating with slow-wave (deep) sleep, in particular shows regular oscillations throughout a good night's sleep. Secretions of various hormones, including renin, growth hormone, and prolactin, correlate positively with delta-wave activity, while secretion of thyroid-stimulating hormone correlates inversely.Heart rate variability, well-known to increase during REM, predictably also correlates inversely with delta-wave oscillations over the ~90-minute cycle.
Homeostatic functions, especially thermoregulation, occur normally during non-REM sleep, but not during REM sleep. Thus, during REM sleep, body temperature tends to drift away from its mean level, and during non-REM sleep, to return to normal. Alternation between the stages therefore maintains body temperature within an acceptable range.
In humans the transition between non-REM and REM is abrupt; in animals, less so.
Researchers have proposed different models to elucidate the undoubtedly complex rhythm of electrochemical processes that result in the regular alternation of REM and NREM sleep. Monoamines are active during NREMS but not REMS, whereas acetylcholine is more active during REMS. The reciprocal interaction model proposed in the 1970s suggested a cyclic give and take between these two systems. More recent theories such as the "flip-flop" model proposed in the 2000s include the regulatory role of in inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
The standard figure given for the average length of the sleep cycle in an adult man is 90 minutes. This figure was popularized by Nathaniel Kleitman around 1963. Other sources give 90-110 minutes or 80-120 minutes.
In neonates the sleep cycle lasts about 50-60 minutes; average length increases as the human grows into adulthood. In cats the sleep cycle lasts about 30 minutes, in rats about 12 minutes, and in elephants up to 120 minutes. (In this regard the ontogeny of the sleep cycle appears proportionate with metabolic processes, which vary in proportion with organism size. However, shorter sleep cycles detected in some elephants complicate this theory.)
The cycle can be defined as lasting from the end of one REM period to the end of the next, or from the beginning of REM, or from the beginning of non-REM stage 2. (The decision of how to mark the periods makes a difference for research purposes because of the unavoidable inclusion or exclusion of the night's first NREM or its final REM phase if directly preceding awakening.)
Humans continue a ~90-minute ultradian rhythm throughout a 24-hour day whether they are asleep or awake. During the period of this cycle corresponding with REM, people tend to daydream more and show less muscle tone. Kleitman and others following have referred to this rhythm as the basic rest-activity cycle, of which the "sleep cycle" would be a manifestation. A difficulty for this theory is the fact that a long non-REM phase almost always precedes REM, regardless of when in the cycle a person falls asleep.
The sleep cycle has proven resistant to systematic alteration by drugs. Although some drugs shorten REM periods, they do not abolish the underlying rhythm. Deliberate REM deprivation shortens the cycle temporarily, as the brain moves into REM sleep more readily (the "REM rebound") in an apparent correction for the deprivation.