Vertical pressure variation is the variation in pressure as a function of elevation. Depending on the fluid in question and the context being referred to, it may also vary significantly in dimensions perpendicular to elevation as well, and these variations have relevance in the context of pressure gradient force and its effects. However, the vertical variation is especially significant, as it results from the pull of gravity on the fluid; namely, for the same given fluid, a decrease in elevation within it corresponds to a taller column of fluid weighing down on that point.
A relatively simple version  of the vertical fluid pressure variation is simply that the pressure difference between two elevations is the product of elevation change, gravity, and density. The equation is as follows:
The delta symbol indicates a change in a given variable. Since g is negative, an increase in height will correspond to a decrease in pressure, which fits with the previously mentioned reasoning about the weight of a column of fluid.
When density and gravity are approximately constant (that is, for relatively small changes in height), simply multiplying height difference, gravity, and density will yield a good approximation of pressure difference. Where different fluids are layered on top of one another, the total pressure difference would be obtained by adding the two pressure differences; the first being from point 1 to the boundary, the second being from the boundary to point 2; which would just involve substituting the ? and ?h values for each fluid and taking the sum of the results. If the density of the fluid varies with height, mathematical integration would be required.
Whether or not density and gravity can be reasonably approximated as constant depends on the level of accuracy needed, but also on the length scale of height difference, as gravity and density also decrease with higher elevation. For density in particular, the fluid in question is also relevant; seawater, for example, is considered an incompressible fluid; its density can vary with height, but much less significantly than that of air. Thus water's density can be more reasonably approximated as constant than that of air, and given the same height difference, the pressure differences in water are approximately equal at any height.
The barometric formula depends only on the height of the fluid chamber, and not on its width or length. Given a large enough height, any pressure may be attained. This feature of hydrostatics has been called the hydrostatic paradox. As expressed by W. H. Besant,
The Dutch scientist Simon Stevin was the first to explain the paradox mathematically. In 1916 Richard Glazebrook mentioned the hydrostatic paradox as he described an arrangement he attributed to Pascal: a heavy weight W rests on a board with area A resting on a fluid bladder connected to a vertical tube with cross-sectional area α. Pouring water of weight w down the tube will eventually raise the heavy weight. Balance of forces leads to the equation
Glazebrook says, "By making the area of the board considerable and that of the tube small, a large weight W can be supported by a small weight w of water. This fact is sometimes described as the hydrostatic paradox."
If one is to analyze the vertical pressure variation of the Atmosphere of Earth, the length scale is very significant (troposphere alone being several kilometres tall; thermosphere being several hundred kilometres) and the involved fluid (air) is compressible. Gravity can still be reasonably approximated as constant, because length scales on the order of kilometres are still small in comparison to Earth's radius, which is on average about 6371 km, and gravity is a function of distance from Earth's core.
Density, on the other hand, varies more significantly with height. It follows from the ideal gas law that
Put more simply, air density depends on air pressure. Given that air pressure also depends on air density, it would be easy to get the impression that this was circular definition, but it is simply interdependency of different variables. This then yields a more accurate formula, of the form
Therefore, instead of pressure being a linear function of height as one might expect from the more simple formula given in the "basic formula" section, it is more accurately represented as an exponential function of height.
Note that even that is a simplification, as temperature also varies with height. However, the temperature variation within the lower layers (troposphere, stratosphere) is only in the dozens of degrees, as opposed to difference between either and absolute zero, which is in the hundreds, so it is a reasonably small difference. For smaller height differences, including those from top to bottom of even the tallest of buildings, (like the CN tower) or for mountains of comparable size, the temperature variation will easily be within the single-digits. (See also lapse rate.)
An alternative derivation, shown by the Portland State Aerospace Society, is used to give height as a function of pressure instead. This may seem counter-intuitive, as pressure results from height rather than vice versa, but such a formula can be useful in finding height based on pressure difference when one knows the latter and not the former. Different formulas are presented for different kinds of approximations; for comparison with the previous formula, the first referenced from the article will be the one applying the same constant-temperature approximation; in which case:
where (with values used in the article)
A more general formula derived in the same article accounts for a linear change in temperature as a function of height (lapse rate), and reduces to above when the temperature is constant:
and the other quantities are the same as those above. This is the recommended formula to use.
Stevin provides an original mathematical demonstration of the so-called hydrostatic paradox