The zenith is an imaginary point directly "above" a particular location, on the imaginary celestial sphere. "Above" means in the vertical direction opposite to the apparent gravitational force at that location. The opposite direction, i.e. the direction in which gravity pulls, is toward the nadir. The zenith is the "highest" point on the celestial sphere (meaning it is the farthest up from the gravitational force).
The word "zenith" derives from an inaccurate reading of the Arabic expression (samt ar-ra's) proposed by ancient Persian astronomers, meaning "direction of the head" or "path above the head", by Medieval Latin scribes in the Middle Ages (during the 14th century), possibly through Old Spanish. It was reduced to 'samt' ("direction") and miswritten as 'senit'/'cenit', as the "m" was misread as an "ni". Through the Old French 'cenith', 'zenith' first appeared in the 17th century.
The term zenith is sometimes used to refer to the highest point, way, or level reached by a celestial body on its daily apparent path around a given point of observation. This sense of the word is often used to describe the position of the Sun ("The sun reached its zenith..."), but to an astronomer, the Sun does not have its own zenith and is at the zenith only if it is directly overhead.
In a scientific context, the zenith is the direction of reference for measuring the zenith angle, the angle between a direction of interest (e.g. a star) and the local zenith.
In astronomy, the altitude in the horizontal coordinate system and the zenith angle are complementary angles, with the horizon perpendicular to the zenith. The astronomical meridian is also determined by the zenith, and is defined as a circle on the celestial sphere that passes through the zenith, nadir, and the celestial poles.
A zenith telescope is a type of telescope designed to point straight up at or near the zenith, and used for precision measurement of star positions, to simplify telescope construction, or both. The NASA Orbital Debris Observatory and the Large Zenith Telescope are both zenith telescopes since the use of liquid mirrors meant these telescopes could only point straight up.
On the International Space Station, zenith and nadir are used instead of up and down, referring to directions within and around the station, relative to the earth.