Combat, cancer and accidents--all can cause devastating nerve injuries. Sometimes, the body heals on its own.
"Your peripheral nerves, the ones in the arms and the face, have an inherent ability to regenerate, but only under ideal circumstances," says University of Florida biomedical engineer Christine Schmidt.
With support from the National Science Foundation (NSF), Schmidt and her team are working to restore nerve function when injuries are more complicated. Surgeons can sometimes move a nerve from one part of a patient's body to another. Schmidt has developed a method that grafts cadaver tissue onto the damaged area to act as a scaffold for nerves to re-grow themselves.
"This medical application has been made possible by developing new tissue engineering methods and by understanding how cells interact with their surroundings," notes Friedrich Srienc, director of the Biotechnology, Biochemical and Biomass Engineering program in NSF's Directorate for Engineering.
Schmidt and her team are also looking at other approaches to directly stimulate nerve growth using as building blocks the natural sugar molecules found in the body. That would eliminate the need to transplant tissue. While the ultimate goal in nerve regeneration is reversing paralysis, Schmidt says intermediate successes, such as improving lung or bladder function, can be invaluable to patients and their families.
The research in this episode was supported by NSF award #0829166, "Direct Write" Techniques to Create Submicron, Arbitrary Protein Structures within Hyaluronan Hydrogels; NSF award #0805298, Crystal Templated Polysaccharide Hydrogels; NSF award #9733156, CAREER: Understanding the Molecular Mechanics of Growth Cone Motility and Nerve Regeneration; NSF award #0201744, Angiogenic Hydrogel Biomaterials to Promote Nerve Regeneration; and NSF Award #0500969, Hyaluronan-based Materials and Size-dependent Mechanisms of Wound Healing.
Miles O'Brien, Science Nation Correspondent
Marsha Walton, Science Nation Producer