|Indiana Intercollegiate Conference|
|Members||7 (charter), 13 (total)|
|Headquarters||Terre Haute, Indiana|
The following year, University of Indianapolis and Ball State University joined. By the late 1940s, virtually every Indiana college; private or public was a member. The notable exceptions were Purdue University, Indiana University and the University of Notre Dame; it was at this time that the Conference splintered into two, the Indiana Collegiate Conference made up of the larger schools and the Hoosier College Conference, comprising the smaller schools. The Hoosier College Conference would ultimately evolve into the late 1980s Heartland Collegiate Athletic Conference.
The IIC was formed in July 1922; largely through the work of three officers, the athletic directors at Indiana State (Birch Bayh), Purdue (Col. Nelson A. Kellogg) and DePauw (Dr. W. M. Blanchard.) 
The IIC had many legendary players and coaches over the years. In basketball, John Wooden, Arad McCutchan, Tony Hinkle, and John Longfellow, all served as head coaches in the conference. Some notable IIC players included Duane Klueh, and Dick Atha.
Football was a conference sanctioned sport from 1934 to 1947, with the Butler Bulldogs dominating the conference by winning league titles from 1934 to 1940, as well as in 1946 and 1947.
The late 1940s and early 1950s saw many of the conference's athletic programs depart for other conferences, however many of the league's larger college programs became part of the Indiana Collegiate Conference which existed until 1978. The smaller schools formed the Hoosier College Conference, which evolved into the Indiana Collegiate Athletic Conference in 1987 and eventually the Heartland Collegiate Athletic Conference.
In 1967, some of the official conference records were moved from Terre Haute, Indiana to the campus of DePauw University, becoming part of the Indiana Intercollegiate Conference/Special Collections Library.
|Team||Left For||Current Home|
|Ball State||Indiana Collegiate Conference||Mid-American Conference|
|Butler||Indiana Collegiate Conference||Big East Conference|
|DePauw||Indiana Collegiate Conference||North Coast Athletic Conference|
|Evansville||Indiana Collegiate Conference||Missouri Valley Conference|
|Earlham||Hoosier College Conference||Heartland Collegiate Athletic Conference|
|Franklin||Hoosier College Conference||Heartland Collegiate Athletic Conference|
|Hanover||Hoosier College Conference||Heartland Collegiate Athletic Conference|
|Indianapolis||Hoosier College Conference||Great Lakes Valley Conference|
|Indiana State||Indiana Collegiate Conference||Missouri Valley Conference|
|Manchester||Hoosier College Conference||Heartland Collegiate Athletic Conference|
|Rose-Hulman||Hoosier College Conference||Heartland Collegiate Athletic Conference|
|Valparaiso||Indiana Collegiate Conference||Horizon League|
|Saint Joseph's||Indiana Collegiate Conference||Great Lakes Valley Conference|
|Wabash||Hoosier College Conference||North Coast Athletic Conference|
Indiana State won Men's Basketball titles in 1947, 1948, 1949 and 1950. In 1948, Indiana State was the Runner-Up in the NAIA National title game. In 1950, Indiana State won the NAIA National Title. DePauw won the conference title in the early 1930s; Central Normal won consecutive titles in 1935-36 & 1936-37.
Indiana State won titles in 1923, 1924, 1930, 1946, 1947, 1949.
No conference championship was awarded in 1943 and 1944 due to World War II.
DePauw's men's tennis team of 1937 and 1941 won the conference title while going undefeated both seasons; 8-0 in 1937 and 14-0 in 1941. The 1941 edition swept the conference while also defeating several Big Ten and SEC opponents